The 2020 OECD statistics show that 9% of the 25-64 year-olds with an educational level below upper secondary school are unemployed. Besides, lots of in-transition workers, unemployed and inactive adults are not joining adult education. In addition, the EU argues that the green transition and digital transformation is likely to unevenly affect sectors. Therefore, the RESCALE project will develop an innovative approach to up- and reskill skills of in-transition workers, unemployed or inactive adults for new tasks and new jobs in particular from declining sectors into the green and digital economy. By developing an innovative infrastructure called the ‘Reskilling Lab’, the labor market position and level of proficiency of transversal, basic, digital and green skills of these vulnerable adults will be improved. First, a comparative analysis will be realized to compare the educational and labor market infrastructures throughout Europe focussing on up- and reskilling skills. As a result an assessment tool for identifying skills among these adults and an innovative European ‘Reskilling Labs’ model will be developed, existing of a blueprint for the European ‘Reskilling Lab’, a model for enhanced career guidance, counselling and mentoring and innovative training materials and -methods. In cooperation with stakeholders like companies, adult education and training providers and public and private organizations ‘Reskilling Labs’ in 7 countries for 210 to 350 in-transition workers, unemployed or inactive adults will be realised. These ‘Reskilling Labs’ will be scientific evaluated. Based on these results a digital European ‘Reskilling Labs’ manual and roadmap for sustainable implementation for professionals will be developed in addition to a policy-model for policy-makers existing of a prototype of a digital decision support system and a business model in order to stimulate effective strategies to up- and reskill skills of in-transition workers, unemployed or inactive adults.